Further investigations regarding the toxicity of sodium nitroprusside.
نویسندگان
چکیده
Sodium nitroprusside is a valuable vasodilator, but its use has been curtailed because of numerous reports that, in the presence of blood, nitroprusside decomposes with release of toxic cyanide. We have examined the release of cyanide in terms of the known chemistry of nitroprusside and suggest that photochemical decomposition of nitroprusside and (or) its metabolism in vivo invalidates the analytical procedure used by previous workers. We also present evidence for the stability of nitroprusside in blood, based on 13C nuclear magnetic resonance studies.
منابع مشابه
Effect of different concentrations of Zinc and their interaction with Sodium nitroprusside (SNP) on physiological and biochemical parameters of Plantago major L. Sara Nasiri Savadkoohi1*, Sakineh Saeidi-sar2 Abbas Ali Dehpour3 and Hossein Abbaspour1
Zinc is a necessary micronutrient in plants whose deficiency can alter essential functions in plant metabolism. High concentrations of Zn can be potentially toxic to plants causing phytotoxicity by the formation of reactive oxygen species. On the other hand, sodium nitroprusside (SNP), a donor of nitric oxide (NO) can protect cells from oxidative damage produce by reactive oxygen species. In th...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 33 4 شماره
صفحات -
تاریخ انتشار 1987